Effects of Chronic Buspirone Treatment on Cocaine Self-Administration

Inhibitory effects of ibogaine on cocaine self-administration in rats.

In order to determine the potential anti-addictive properties of ibogaine, we used the cocaine self-administration model in rats. The results indicate that a single injection of ibogaine (40 mg/kg i.p.) produced a significant decrease of cocaine intake, which remained unaltered for more than 48 h. Since the half-life time of ibogaine is short, this might suggest the involvement of one or severa...

Effects of chronic oral methylphenidate on cocaine self-administration and striatal dopamine D2 receptors in rodents.

BACKGROUND Methylphenidate (MP) and amphetamine, which are the mainstay for the treatment of ADHD, have raised concerns because of their reinforcing effects and the fear that their chronic use during childhood or adolescence could induce changes in the brain that could facilitate drug abuse in adulthood. METHODS Here we measured the effects of chronic treatment (8 months) with oral MP (1 or 2...

The Effects of Chronic Cocaine Self-Administration on Cognition and Brain Metabolism

The effects of chronic cocaine self-administration on the menstrual cycle in rhesus monkeys.

Clinical studies suggest that cocaine disrupts reproductive function, but because cocaine abusers often abuse opiates and alcohol, it has been difficult to determine the contribution of cocaine alone. The effects of chronic cocaine self-administration on menstrual cycle duration and basal levels of progesterone were examined in eight female rhesus monkeys and compared with the effects of occasi...

The expanding effects of cocaine: studies in a nonhuman primate model of cocaine self-administration.

Although neuroimaging investigations in human cocaine abusers have provided important insights into the brain changes that accompany drug use, the interpretation of reports in human abusers can be very difficult. Studies in nonhuman primates provide a way to systematically evaluate the structural and functional adaptations engendered by cocaine self-administration without the confounds of human...